1 Design, Construction and Characterization of Stimuli (redox potential, pH, light…) Responsive Polymeric Gene/Drug Delivery Systems; 
2 Development of Nanomaterials for tumor diagnostic and therapeutic applications; 
3 Development of Novel Biomaterials for Tissue Engineering.

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2001-09--2007-06   Î人´óѧ   Àíѧ²©Ê¿
1997-09--2001-06   Î人´óѧ   Àíѧѧʿ

   

Ph.D

 

   

2013-02~ÏÖÔÚ, Öйú¿ÆѧԺ¸ßÄÜÎïÀíÑо¿Ëù, ¸±Ñо¿Ô±
2012-02~2013-01,University of Manitoba, ÖúÀíÑо¿Ô±
2009-02~2012-01,University of Manitoba, ²©Ê¿ºó
2007-09~2008-11,Wayne State University, ²©Ê¿ºó

   

   

   

£¨1£© ÖпÆÔºÇàÄ괴дٽø»á, ÌصȽ±, ²¿Î¯¼¶, 2015

£¨ 1 £© Multifunctional nanoparticle for doxorubicin enhanced intracellular delivery, ·¢Ã÷, 2012, µÚ 1 ×÷Õß, ×¨ÀûºÅ: 61/586,833
£¨ 2 £© °¢Ã¹ËØÇ°Ò©¼°ÆäÖƱ¸·½·¨ºÍ¿É×¢ÉäµÄ×éºÏÎï, ÊµÓÃÐÂÐÍ, 2013, µÚ 1 ×÷Õß, ×¨ÀûºÅ: CN103381273-A
£¨ 3 £© Ò»ÖÖÁ½Ç×ÐÔ¾ÛºÏÎïÒÔ¼°ÓÉÆäÐγɵĴÅÐÔ½ºÊøÄÉÃ×ÔØÌåºÍÆäÓÃ;, ·¢Ã÷, 2018, µÚ 1 ×÷Õß, ×¨ÀûºÅ: ZL201610819749.8
£¨ 4 £© Ò»ÖÖ¾ÛÒÒ¶þ´¼/¾Ûõ£°·°·¹²¾ÛÎï¡¢ÆäÖƱ¸·½·¨¼°°üº¬¸Ã¹²¾ÛÎïµÄÁ½Ç×ÐÔsiRNAÔØÌå, ·¢Ã÷, 2019, µÚ 1 ×÷Õß, ×¨ÀûºÅ: ZL201610817502.2
£¨ 5 £© Ò»ÖÖÁ£¾¶¿É¿ØµÄ°¢Ã¹ËØÄÉÃ׿ÅÁ£¼°ÆäÖƱ¸·½·¨, ·¢Ã÷, 2019, µÚ 1 ×÷Õß, ×¨ÀûºÅ: ZL201610819358.6

   

£¨1£© A thermoresponsive nanocarrier for mitochondria-targeted drug delivery., Chem Commun, 2019, Í¨Ñ¶×÷Õß
£¨2£© Triplet Tellurophene-Based Semiconducting Polymer Nanoparticles for Near-Infrared-Mediated Cancer Theranostics., Acs Appl. Mater. Interfaces,, 2019, µÚ 3 ×÷Õß
£¨3£© Light-Triggered PEGylation/dePEGylation of the Nanocarriers for Enhanced Tumor Penetration,, Nano Letters, 2019, Í¨Ñ¶×÷Õß
£¨4£© AMPK mediates the neurotoxicity of iron oxide nanoparticles retained in mitochondria or lysosomes,, Metallomics, 2019, Í¨Ñ¶×÷Õß
£¨5£© Gold Nanoparticle-Based Probe for Analyzing Mitochondrial Temperature in Living Cells,, ACS Appl. Bio Mater., 2019, Í¨Ñ¶×÷Õß
£¨6£© In vivo evaluation of near-infrared mediated nanoplatforms for targeted chemo-photothermal therapy and photothermo-immunotherapy,, Nanomedicine: Nanotechnology, Biology, and Medicine,, 2018, Í¨Ñ¶×÷Õß
£¨7£© Integration of Cell-Penetrating Peptides with Rod-like Bionanoparticles: Virus-Inspired Gene-Silencing Technology, Nano Letters, 2018, µÚ 8 ×÷Õß
£¨8£© Near Infrared/pH Dual-Sensitive Nanocarriers for Enhanced Intracellular Delivery of Doxorubicin, Acs Biomater Sci Eng,, 2018, Í¨Ñ¶×÷Õß
£¨9£© pH-Sensitive Poly(β-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells,, Nanomaterials, 2018, Í¨Ñ¶×÷Õß
£¨10£© ÅÁ½ðÉ­²¡ÖеĹؼü½ðÊôÔªËØ, Neurotoxicity of Key Metals in Parkinson’s Disease, »¯Ñ§½øÕ¹£¨Progress in Chemistry£©, 2018, µÚ 2 ×÷Õß
£¨11£© Significant Enhancement of Photothermal and Photoacoustic Efficiencies for Semiconducting Polymer Nanoparticles through Simply Molecular Engineering, Adv. Funct. Mater., 2018, µÚ 3 ×÷Õß
£¨12£© Iron-induced generation of mitochondrial ROS depends on AMPK activity, Biometals, 2017, µÚ 2 ×÷Õß
£¨13£© Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells, Biometals, 2017, µÚ 2 ×÷Õß
£¨14£© Mitochondria-targeted nanocarriers using hyperbranched polycations wrapped carbon nanotubes for augment photodynamic therapeutic effects, J Control Release, 2017, Í¨Ñ¶×÷Õß
£¨15£© A facile construction of pH-sensitive shell-sheddable supramolecular nanoassembly codelivery anticancer drugs to combat drug resistance, J Control Release, 2017, Í¨Ñ¶×÷Õß
£¨16£© In vivo chemo/photothermal therapy using near-infrared light triggered switchable nanoparticles against subcutaneous and orthotopic superficial bladder cancer, J Control Release, 2017, Í¨Ñ¶×÷Õß
£¨17£© Two mTOR inhibitors, rapamycin and Torin 1, differentially regulate iron-induced generation of mitochondrial ROS, Biometals, 2017, µÚ 2 ×÷Õß
£¨18£© Near-Infrared Guided Thermal-Responsive Nanomedicine against Orthotopic Superficial Bladder Cancer, Acs Biomater Sci Eng,, 2017, Í¨Ñ¶×÷Õß
£¨19£© Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects, Biomater. Sci., 2017, Í¨Ñ¶×÷Õß
£¨20£© The Application of Stimuli-responsive Nanocarriers for Targeted Drug Delivery., Curr. Top. Med. Chem., 2017, Í¨Ñ¶×÷Õß
£¨21£© mTOR Signaling in Parkinson's Disease, Neuromolecular Med., 2017, µÚ 2 ×÷Õß
£¨22£© Two mTOR inhibitors, rapamycin and Torin 1, differentially regulate iron-induced generation of mitochondrial ROS, Biometals, 2017, µÚ 2 ×÷Õß
£¨23£© AMPK Inhibition Enhances the Neurotoxicity of Cu(II) in SH-SY5Y Cells., Neurotox. Res., 2016, µÚ 3 ×÷Õß
£¨24£© The Neurotoxicity of Iron, Copper and Cobalt in Parkinson’s Disease Through ROS-Mediated Mechanisms., Biometals, 2016, µÚ 2 ×÷Õß
£¨25£© Characterization and Preclinical Perspectives of Organic Small Molecule Drug Metabolites in Drug-Drug Interactions., Curr. Org. Chem., 2016, µÚ 2 ×÷Õß
£¨26£© A thiol fluorescent probe reveals the intricate modulation of cysteine's reactivity by Cu(II), Talanta, 2016, µÚ 3 ×÷Õß
£¨27£© High-Throughput Screening of Substrate Specificity for Protein Tyrosine Phosphatases (PTPs) on Phosphopeptide Microarrays, Methods Mol. Biol., 2016, µÚ 3 ×÷Õß
£¨28£© Reduction sensitive micellar magnetic nanoparticles for cancer targeted chemotherapy, Nanomed.-Nanotechnol. Biol. Med., 2016, Í¨Ñ¶×÷Õß
£¨29£© Peptide-Decorated Gold Nanoparticles as Functional Nano-Capping Agent of Mesoporous Silica Container for Targeting Drug Delivery, ACS Appl. Mater. Interfaces, 2016, µÚ 4 ×÷Õß
£¨30£© Near-Infrared Light-Triggered Switchable Nanoparticles for Targeted Chemo/Photothermal Cancer Therapy, ACS Appl. Mater. Interfaces, 2016, Í¨Ñ¶×÷Õß
£¨31£© Near-infrared light remote-controlled intracellular anti-cancer drug delivery using thermo/pH sensitive nanovehicle, Acta Biomater., 2015, Í¨Ñ¶×÷Õß
£¨32£© Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand, Metallomics, 2015, µÚ 3 ×÷Õß
£¨33£© A Facile Strategy for In Situ Controlled Delivery of Doxorubicin with a pH-Sensitive Injectable Hydrogel, Nano Life, 2014, Í¨Ñ¶×÷Õß
£¨34£© Reducible polyamidoamine-magnetic iron oxide self-assembled nanoparticles for doxorubicin delivery, Biomaterials, 2014, µÚ 1 ×÷Õß
£¨35£©  Free-Standing Cell Sheet Assembled with Ultrathin Extracellular Matrix as an Innovative Approach for Biomimetic Tissues, Advanced Functional Materials, 2014, µÚ 1 ×÷Õß
£¨36£©  Engineering the heart: Evaluation of conductive nanomaterials for improving implant integration and cardiac function, Scientific Reports, 2014, µÚ 1 ×÷Õß
£¨37£© A PNIPAAm-based thermosensitive hydrogel containing SWCNTs for stem cell transplantation in myocardial repair, Biomaterials, 2014, µÚ 4 ×÷Õß
£¨38£© Photo-cross-linked and pH-Sensitive Biodegradable Micelles for Doxorubicin Delivery, ACS Appl. Mater. Interfaces, 2013, µÚ 1 ×÷Õß
£¨39£© Opposing influence of intracellular and membrane thiols on the toxicity of reducible polycations, Biomaterials, 2013, µÚ 4 ×÷Õß
£¨40£© Reducible self-assembled micelles for enhanced intracellular delivery of doxorubicin, J. Mater. Chem., 2012, µÚ 1 ×÷Õß
£¨41£© pH and Reduction Dual-Sensitive Copolymeric Micelles for Intracellular Doxorubicin Delivery, Biomacromolecules, 2012, µÚ 1 ×÷Õß
£¨42£© Effect of cell membrane thiols and reduction-triggered disassembly on transfection activity of bioreducible polyplexes, European Journal of Pharmaceutical Sciences, 2012, µÚ 3 ×÷Õß
£¨43£© Multifunctional Nanofibrous Scaffolds Based on Poly(L-lactic acid) and Poly(L-lactic acid)-Poly(ethylene glycol) for Tissue Engineering, International Journal of Nanomedicine, 2011, µÚ 1 ×÷Õß
£¨44£© Degradable micelles based on hydrolytically degradable amphiphilic graft copolymers for doxorubicin delivery, Polymer, 2011, µÚ 1 ×÷Õß
£¨45£© Novel Poly(amidoamine)s with Pendant Primary Amines as Highly Efficient Gene Delivery Vectors, Macromolecular Bioscience, 2010, µÚ 2 ×÷Õß
£¨46£© Bioreducible hyperbranched poly(amido amine)s for gene delivery, Biomacromolecules, 2009, µÚ 1 ×÷Õß
£¨47£© Poly(beta-aminoester)s with pendant primary amines for efficient gene delivery, Bioconjugate Chemistry, 2009, µÚ 2 ×÷Õß
£¨48£© Effect of intracellular glutathione levels on the cytotoxicity of bioreducible polycations, Molecular Therapy, 2009, µÚ 2 ×÷Õß
£¨49£© Effect of Nucleic Acid Size on Physical Properties and Biological Activity of Redox-Responsive Polyplexes: Plasmid DNA vs. Antisense Oligonucleotides, Molecular Therapy, 2009, µÚ 3 ×÷Õß
£¨50£© A cleavable-polycation template method for the fabrication of noncrosslinked, porous polyelectrolyte multilayered films, Advanced Materials, 2007, µÚ 1 ×÷Õß
£¨51£© Tunable film degradation and sustained release of plasmid DNA from cleavable polycation/plasmid DNA multilayers under reductive conditions, Small, 2007, µÚ 1 ×÷Õß
£¨52£© Synthesis and degradation of poly(beta-aminoester) with pendant primary amine, Polymer, 2007, µÚ 1 ×÷Õß

   

   

£¨ 1 £© ÓÃÓÚ°©Ö¢Õï¶ÏÖÎÁƵÄÄÉÃ×ÔØÌåµÄÑо¿, Ö÷³Ö, Êеؼ¶, 2013-02--2016-01
£¨ 2 £© ½üºìÍâ¹âÃô¶à¹¦ÄÜÄÉÃ×ÔØÌåµÄ¹¹½¨¼°Ò©Îï°ÐÏò´«µÝºÍ³ÉÏñÑо¿, Ö÷³Ö, ¹ú¼Ò¼¶, 2014-01--2016-12
£¨ 3 £© ¸Î°©ÔçÆÚÕï¶ÏÓÃÐÂÐÍÄÉÃײÄÁϵÄÉè¼ÆºÍ¹¹Öþ, ²ÎÓë, ¹ú¼Ò¼¶, 2012-09--2015-08
£¨ 4 £© »ùÓÚ°ûÄÚ¶àÖÖÉúÎï»îÐÔ·Ö×Óͬʱʶ±ðµÄÓ«¹â̽ÕëÑо¿, ²ÎÓë, ¹ú¼Ò¼¶, 2014-01--2018-12
£¨ 5 £© Öйú¿ÆѧԺÇàÄ괴дٽø»á, Ö÷³Ö, ²¿Î¯¼¶, 2015-01--2018-12
£¨ 6 £© ¶àÖش̼¤ÏìÓ¦ÐÔÄÉÃ×Ò©ÎïµÄ¹âÈÈÖÎÁÆÓ뻯ÁƵÄЭͬ¿¹Ö×ÁöÑо¿, Ö÷³Ö, ¹ú¼Ò¼¶, 2016-01--2019-12

£¨1£©¹âÈÈ/»¯ÁÆÁªºÏÃâÒßÖÎÁÆÄÉÃ׸´ºÏÒ©ÎïµÄ¿¹Ö×ÁöÑо¿   2017 ÖйúÉúÎï²ÄÁÏ´ó»á   2017-10-27
£¨2£©Near-Infrared Guided Switchable Nanoparticles for Enhanced Targeted Therapy againstSubcutaneous and Orthotopic Bladder Cancer   ÃÀ¹ú²ÄÁÏѧ»á2016Çï¼¾Äê»á£¨Materials Research Society 2016 Fall Meeting£©   2016-11-27
£¨3£©In Vivo Evaluation of Near-Infrared Mediated Nanoplatforms for Targeted Chemo-Photothermal Therapy and Photothermo-Immunotherapy   µÚ¶þ½ì¹ú¼ÊÄÉÃ×Ò©Îï´ó»á   2016-10-18
£¨4£©¶ÀÁ¢Ï¸°ûĤƬÓë²ã²ã×éװϸ°ûÍâ»ùÖÊÖƱ¸·ÂÉú×éÖ¯   2015 ÖйúÉúÎï²ÄÁÏ´ó»áôßÖÐÃÀÉúÎï²ÄÁÏѧ»áµÚÈý´ÎרÌâÂÛ̳   2015-11-19
£¨5£©»¹Ô­½µ½âÐÔ¾ÛÑôÀë×ÓµÄϸ°û¶¾ÐԵĻúÀíÑо¿   Öйú¶¾Àíѧ»áµÚÆß´ÎÈ«¹ú¶¾Àíѧ´ó»á   2015-10-25
£¨6£©¹âÖ³ߴç±ä»»ÐÍÄÉÃ×ÔØÌåÓÃÓÚ°òë×°©µÄ°ÐÏòÈÈ»¯ÁÆÑо¿   2015ÄêÈ«¹ú¸ß·Ö×ÓѧÊõÂÛÎı¨¸æ»á   2015-10-17
£¨7£©Photothermally Size-Switchable Nanocarriers for Near Infrared Laser Guided Tumor Targeted Chemo/Photothermal Therapy    Öйú»¯Ñ§»áµÚÊ®Îå½ì½ºÌåÓë½çÃ滯ѧ»áÒé   2015-07-17
£¨8£©Photothermally Switchable Nanocarriers for Near Infrared Laser Guided Tumor Targeted Chemo/Photothermal Therapy    µÚ10½ìÖÐÃÀÄÉÃ×ÂÛ̳   Ying Bi, Hui Gao, Yi Hu, Jun Chen,*   2015-06-26
£¨9£©Preparation of Thermal/pH Dual Responsive Nanocarriers for Near Infrared Laser Guided Tumor Targeted Chemo/Photothermal Therapy    2015ÄêÃÀ¹úÉúÎï²ÄÁÏѧ»áÄê»á£¨2015 Annual Meeting of Society for Biomaterials£©   Ying Bi, Hui Gao, Aiping Lan, Yi Hu, Jun Chen*   2015-04-19
£¨10£©Free-Standing Cell Sheet Assembled with Ultrathin Extracellular Matrix as an Innovative Approach for Biomimetic Tissues   µÚÎå½ìÖÐÅ·ÉúÎï²ÄÁÏ´ó»á   Peng Chen, Ying Bi, Xiaozhong Qiu, Yi Hu, Malcolm M. Q. Xing, Jun Chen*   2015-04-14
£¨11£©Redution Sensitive Micellar Magnatic Nanoparticles for Cancer Targeted Chemotherapy   2015ÄêÄÉÃ×Ò©ÎïÓëÄÉÃ×ÉúÎï¼¼Êõ¹ú¼Ê»áÒé   Hui Zhou, Ying Bi, Jun Chen*, Yi Hu   2015-04-13
£¨12£©Near-infrared light remote-enhanced tumor targeting chemo-photothermal co-therapy using thermo/pH sensitive nanovehicle   2015ת»¯ÄÉÃ×ҽѧ¹ú¼ÊѧÊõÑÐÌֻᠠ Ying Bi, Yi Hu*, Yuliang Zhao, Jimin Gao, Jun Chen*   2015-01-12
£¨13£©Í¬²½·øÉä¼¼Êõ¼ì²â¼×»ù¹¯ÔÚË®µ¾ÖеÄתÔË   2014Äê±±¾©Í¬²½·øÉä×°ÖÃÓû§Ñ§ÊõÄê»áôßר¼Ò»á   ÕÔ¼×ͤ£¬³Â¿¡£¬ºúÒ㣬¸ßÓúÏ£    2014-08-12
£¨14£©Preparation of Biocompatible Conductive Nanomaterials for Improving Myocardial Repair   2014Äê¹ú¼Ê¸ß·Ö×Ó»¯Ñ§Ñ§ÊõÑÐÌֻᠠ Ying Bi, Xiaohan Xu, Yanping Qin, Hui Zhou, Yi Hu, Jun Chen,   2014-06-04
£¨15£©Controlled release of Doxorubicin from pH and reducing agents dual responsive PEG-Reducible Poly(beta-amino ester)s-PEG micelles   239½ìÃÀ¹ú»¯Ñ§Ñ§»áÄê»á   Jun Chen, Shufei Zhou and Wen Zhong   2010-05-20
£¨16£©Effect of intracellular glutathione levels on the cytotoxicity of bioreducible polycations   20½ìÃÀ¹ú»ùÒòÖÎÁÆѧ»áÄê»á   Chao Wu, Jun Chen, Jing Li, David Oupicky   2009-05-27
£¨17£©Synthesis and characterization of hyperbranched poly(amido amine)s for gene delivery   µÚ35½ìÃÀ¹ú¿ØÖÆÊÍ·Åѧ»áÄê»á   Ye-Zi You, Jun Chen, Devika S Manickam, Qing-Hui Zhou, Lei Wan, Guangzhao Mao and David Oupicky   2008-07-12
£¨18£©¾Ûõ¥-°·ÑôÀë×Ó/ÖÊÁ£DNA ¶à²ãĤµÄ¹¹½¨¼°Æä¿ØÖÆÊÍ·ÅDNA   2005 È«¹ú¸ß·Ö×ÓѧÊõÂÛÎı¨¸æ»á   ³Â¿¡£¬»ÆÊÀÎÄ£¬ÁÖÎĺ££¬×¿ÈÊìû   2005-10-18

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