中国科学院化学研究所导师方晓红
作者：科大科院考研网 发表时间：2019-11-14 来源：研招办
科院考研推荐链接：
方晓红 女 博导 中国科学院化学研究所
电子邮件： xfang@iccas.ac.cn
通信地址： 北京海淀中关村北一街2号
邮政编码： 100190
研究领域
Ø 生物单分子荧光成像及单分子力谱
Ø 蛋白质实时检测新探针
Ø 纳米生物传感器
教育背景
学历
学位
1990武汉大学理学学士
1993北京大学理学硕士
1996北京大学理学博士
出国学习工作
1997-1998加拿大滑铁卢大学博士后
1998-2001美国佛罗里达大学研究助理教授课程
专利与奖励
奖励信息
1.中科院引进国外杰出人才（****，2001年），
2.国家自然科学基金委杰出青年科学基金 (2003年)
3.中国化学会青年化学奖(2003年)
4.中科院****优秀入选者 (2005年)
5.中科院十大杰出妇女（2006年）
6.“新世纪百千万人才工程”国家级人选（2006年）
7.中国分析测试学会青年工作奖（2008年）
8. 中国侨界创新人才贡献奖 （2010年）
9．国务院政府特殊津贴（2010年）
2.国家自然科学基金委杰出青年科学基金 (2003年)
3.中国化学会青年化学奖(2003年)
4.中科院****优秀入选者 (2005年)
5.中科院十大杰出妇女（2006年）
6.“新世纪百千万人才工程”国家级人选（2006年）
7.中国分析测试学会青年工作奖（2008年）
8. 中国侨界创新人才贡献奖 （2010年）
9．国务院政府特殊津贴（2010年）
专利成果
出版信息
发表论文
代表性论文(from more than 110) ：
Single-Molecule Detection of Proteins Using Aptamer-Functionalized Molecular Electronic Devices, Liu, S.; Zhang, X., Luo, W., Wang, Z.., Guo, X.*, Steigerwald, M., Fang, X.*, Angew. Chem. Int. Ed. 2011,DOI: 10.1002/anie.201006469
A single-molecule study of inhibition effect of Naringenin on transforming growth factor-b ligand-receptor binding, Yang, Y., Xu, Y., Xia, T., Chen, F., Zhang, F., Liang, W., Fang, X.* , Chem. Commun. 2011, 47, 2982-2984
A Water-Soluble C60-Porphyrin Compound for Highly Efficient DNA Photocleavage, Zhou, C.*, Liu, Q., Xu, W., Wang, C. and Fang, X.*, Chem. Commun., 2011, 47, 2982-2984
Elasticity of Cardiac Cells on the Polymer Substrates with Different Stiffness: An Atomic Force Microscopy Study, Shi, X., Qin, L., Zhang, X., He, K., Xiong, C., Fang, J., Fang, X.*, Zhang, Y.*, Phys. Chem. Chem. Phys., 2011, 13 (16), 7540-5.
Single-Molecule Imaging Revealed Enhanced Dimerization of Transforming Growth Factor β Type Ⅱ Receptors in Hypertrophic Cardiomyocytes” He, K., Fu, Y., Zhang, W., Yuan, J., Li, Z., Lv, Z., Zhang, Y*, Fang, X.* Biochem. Biophy. Res. Commun., 2011,407，313-317.
Single-molecule fluorescence imaging of membrane-bound proteins for studies of cell signaling transduction，Yang, Y., Xia, T., Zhang, W., Fang, X.* Chinese Science Bulletin, 2011, 56(11), 1063-67.
TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs. Huang T, David L, Mendoza V, Yang Y, Villarreal M, De K, Sun L, Fang X, López-Casillas F, Wrana JL, Hinck AP，EMBO J. 2011，30(7): 1263-76.
Aptamers Generated from Cell-SELEX for Molecular Medicine：A Chemical Biology Approach, Fang, X.* and Tan, W*, Acc. Chem. Res., 2010, 43, 48-57.
Intercellular transportation of quantum dots mediated by membrane nanotubes, He, K., Luo, W., Zhang, Y., Liu, F., Liu, D., Xu, L., Qin, L., Xiaong, C., Lu, Z., Fang, X.*, Zhang, Y.*, ACS Nano, 2010, 4，3015-3022.
Study of the inhibitory effect of water-soluble fullerenes on plant growth at the cellular level. Liu, Q., Zhao, Y., Wan, Y., Zhang, J., Zhang, X., Wang, C., Fang, X. * and Lin., J.* , ACS Nano, 2010, 4，5743-5748.
Monomeric Type I and Type III Transforming Growth Factor-β Receptors and Their Dimerization, Zhang, Z., Yuan, J., Yang, Y., Xu, L., Wang, Q., Fang, X.*, Chen, Y.*, Cell Res., 2010. 20，1216-1223.
Single-Molecule Imaging Reveals Transforming Growth Factor-b-induced Type II Receptor Dimerization. Zhang, W., Jiang, Y., Wang , Q., Ma, X., Xiao, Z., Zuo, W., Fang, X.*, Chen, Y.* Proc. Natl. Acad. Sci. USA, 2009, 106, 15679-15683.
Carbon Nanotubes as Molecular Transporters for Walled Plant Cells, Liu, Q., Bo. C., Wang, Q., Shi, X., Xiao, Z., Lin., J., and Fang, X. *, Nano Letters, 2009, 9: 1007-1010.
Study of inhibition effect of herceptin on interaction between heregulin and ErbB receptors HER3/HER2 by single-molecule force spectroscopy, Shi, X., Xu, L., Yu., J., and Fang, X. *, Exp. Cell. Res. 2009.
Molecular engineering of DNA: molecular beacons.K. Wang*, Z. Tang, C. Yang, Y. M. Kim, X. Fang, W. Li, Y. Wu, C. Medley, Z. Cao, J. Li, P. Colon, H. Lin, W. Tan*. Angew. Chem. Int. Ed., 2009, 48, 856-870.
Hydrodynamically Focused Stream as a Dynamic Template for Site-Specific Electrochemical Micropatterning of Conducting Polymers, Hou, S., Wang, S., Zeta, T., Yu, F., Nicole, Q., Zhu, M., Clifton, K,. Shen, F., Fang, X. *, Tseng, H.*, Angew. Chem. Int. Ed. 2008, 47,1072-1075
Single-Molecule Study of Lateral Mobility of Epidermal Growth Factor Receptor 2/HER2 on Activation，Z. Xiao, X. Ma, Y. Jiang, Z. Zhao, B. Lai, J. Liao, J. Yue and X. Fang*，J. Phy. Chem. B, 2008, 112: 4140-4145.
Detection of trace Hg2+ via induced circular dichroism of DNA wrapped around single-walled carbon nanotubes. X. Gao, G. Xing, Y. Yang, X. Shi, R. Liu, W. Chu, L. Jing, F. Zhao, C. Ye, H. Yuan, X. Fang, C. Wang, and Y. Zhao. J. Am. Chem. Soc., 2008, 130: 9190–9191.
TINY, a dehydration-responsive element(DRE)-binding protein-like transcription factor connecting the DRE-and ethylene-responsive element-mediated signaling patheways in Arabidopsis. S. Sun, J. Yu, F. Chen, T. Zhao, X. Fang, Y. Li, and S. Sui. J. Biol. Chem. 2008, 283: 6261-6271.
Single-Molecule Study of EGFR Mobility Implicates the its Association with Caveolae/Clathrin After Activation，Z. Xiao, W. Zhang, Y. Yang, L. Xu, X. Fang* Biochem Biophys Res Commun. 2008, 369: 730-734.
Conjugation of a Water-Soluble Gadolinium Endohedral Fulleride with an Antibody as a Magnetic Resonance Imaging Contrast Agent， Shu，C., Ma, X., Zhang, J., Corwin, F., Sim, J., Zhang, E., Dorn, H., Gibson, H., Fatouros, P., Wang, C.*, Fang, X. * Bioconjugate Chem., 2008, 19: 651-655.
Cell-specific Internalization study of an Aptamer From Whole Cell Selection, Xiao, Z., Shangguan, D., Cao, Z., Fang, X. and Tan, W. *, Chem. Eur. J., 2008, 14, 1679-1755.
Single Molecule Force Spectroscopy Study of Interaction between Transforming Growth Factor B and its Receptor in Living Cells，Yu., J., Wang Q., Shi X. , Ma, X., Yang H., Chen, Y., Fang, X*, J. Phy. Chem. B, 2007, 111(48):13619-13625
Lateral Diffusion of TGF-b Type Receptor Studied by Single Molecule Imaging, Ma, X., Wang,Q., Jiang, Y., Xiao, Z., Fang, X. *, Chen, Y*., Biochem Biophys Res Commun. 2007, 292, 31-40.
Interaction between Single Molecules of Mac-1 and ICAM-1 in Living Cells: An Atomic Force Microscopy Study, Yang, H., Yu, J. Fu, G., Shi, X., Xiao, L., Chen, Y., Fang, X*., Chen, H*., Exp. Cell. Res. 2007, 331, 3497-3504
Energy Landscape of Aptamer/Protein Complex Studied by Single Molecular Force Spectroscopy, Yu., J., Jiang, Y., Ma, X., Fang, X. * Chem. Asia. J., 2007, 2, 284-289.
Fluorescence study of DNA binding and bending by EcoRI DNA methyltransferase, Ma，B., Wang, J., Fang, X. *, J. Phy. Chem. B, 2006,110, 19647-19651.
Single Molecule Study of Binding Force Between Transcription Factor TINY and Its DNA Responsive Element, Yu, J., Sun, S., Jiang, Y., Ma, X., Chen, F., Zhang, G., Fang, X*., Polymer, 2006, 47, 2533-2538.
Detection of Oncoprotein Platelet-Derived Growth Factor Using Fluorescent Signaling Complex of Aptamer and TOTO，Zhou, C. Wang, J., Jiang, Y., Hou, S., Fang, X. *, Anal. Bioanal. Chem., 2006, 384, 1175-1180.
Aptamer Based ATP Assay Using a Luminescent Light Switching Complex, Wang, J., Jiang, Y., Zhou, C., Fang, X *. Anal. Chem., 2005, 77,3542-3546. (5.6)
Study of Fibrinogen Adsorption on Self-Assembled Monolayers on Au(111) by Atomic Force Microscopy，Lin ,Y., Wang, J., Wan L. , Fang X. *, Ultramicroscopy, 2005, 105, 129-136.
Study of the Single Molecular Interaction of the Transcription Factor ZmDREB1A with its DNA Responsive Element by Atomic Force Microscopy. Jiang, Y. X., Feng, Q., Fang, X*, Bai, C *. Nucl.Acid.Res. 2004, 32(12): e101.
Signaling Aptamer/Protein Binding by a Molecular Light-Switch Complex. Jiang, Y., Fang, X *, Bai, C *. Anal. Chem. 2004, 76, 5230-5235.
Delaying Photobleaching and Recovering Luminescence of a DNA Molecular Light Switch in DNA Analysis, Ling, L., Jiang, Y., Wang, C., Fang, X.*, Wan, L. He, Z., Bai, C.*, Chen.,D.*, Anal. Biochem. 2004, 329, 334-336.
Specific Aptamer - Protein Interaction Studied by Atomic Force Microscopy. Jiang, Y., Zhu, C. F., Ling, L., Wan, L., Fang, X *, Bai, C.*, Anal. Chem., 2003, 75(9): 2112-2116.
Study of Citrate Adsorbed on the Au(111) Surface by Scanning Probe Microscopy. Lin, Y., Pan, G.., Su, G. ., Fang, X.*, Wan, L.*., Bai, C.*. Langmuir 2003, 19, 10000-1003
Single-Molecule Detection of Proteins Using Aptamer-Functionalized Molecular Electronic Devices, Liu, S.; Zhang, X., Luo, W., Wang, Z.., Guo, X.*, Steigerwald, M., Fang, X.*, Angew. Chem. Int. Ed. 2011,DOI: 10.1002/anie.201006469
A single-molecule study of inhibition effect of Naringenin on transforming growth factor-b ligand-receptor binding, Yang, Y., Xu, Y., Xia, T., Chen, F., Zhang, F., Liang, W., Fang, X.* , Chem. Commun. 2011, 47, 2982-2984
A Water-Soluble C60-Porphyrin Compound for Highly Efficient DNA Photocleavage, Zhou, C.*, Liu, Q., Xu, W., Wang, C. and Fang, X.*, Chem. Commun., 2011, 47, 2982-2984
Elasticity of Cardiac Cells on the Polymer Substrates with Different Stiffness: An Atomic Force Microscopy Study, Shi, X., Qin, L., Zhang, X., He, K., Xiong, C., Fang, J., Fang, X.*, Zhang, Y.*, Phys. Chem. Chem. Phys., 2011, 13 (16), 7540-5.
Single-Molecule Imaging Revealed Enhanced Dimerization of Transforming Growth Factor β Type Ⅱ Receptors in Hypertrophic Cardiomyocytes” He, K., Fu, Y., Zhang, W., Yuan, J., Li, Z., Lv, Z., Zhang, Y*, Fang, X.* Biochem. Biophy. Res. Commun., 2011,407，313-317.
Single-molecule fluorescence imaging of membrane-bound proteins for studies of cell signaling transduction，Yang, Y., Xia, T., Zhang, W., Fang, X.* Chinese Science Bulletin, 2011, 56(11), 1063-67.
TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs. Huang T, David L, Mendoza V, Yang Y, Villarreal M, De K, Sun L, Fang X, López-Casillas F, Wrana JL, Hinck AP，EMBO J. 2011，30(7): 1263-76.
Aptamers Generated from Cell-SELEX for Molecular Medicine：A Chemical Biology Approach, Fang, X.* and Tan, W*, Acc. Chem. Res., 2010, 43, 48-57.
Intercellular transportation of quantum dots mediated by membrane nanotubes, He, K., Luo, W., Zhang, Y., Liu, F., Liu, D., Xu, L., Qin, L., Xiaong, C., Lu, Z., Fang, X.*, Zhang, Y.*, ACS Nano, 2010, 4，3015-3022.
Study of the inhibitory effect of water-soluble fullerenes on plant growth at the cellular level. Liu, Q., Zhao, Y., Wan, Y., Zhang, J., Zhang, X., Wang, C., Fang, X. * and Lin., J.* , ACS Nano, 2010, 4，5743-5748.
Monomeric Type I and Type III Transforming Growth Factor-β Receptors and Their Dimerization, Zhang, Z., Yuan, J., Yang, Y., Xu, L., Wang, Q., Fang, X.*, Chen, Y.*, Cell Res., 2010. 20，1216-1223.
Single-Molecule Imaging Reveals Transforming Growth Factor-b-induced Type II Receptor Dimerization. Zhang, W., Jiang, Y., Wang , Q., Ma, X., Xiao, Z., Zuo, W., Fang, X.*, Chen, Y.* Proc. Natl. Acad. Sci. USA, 2009, 106, 15679-15683.
Carbon Nanotubes as Molecular Transporters for Walled Plant Cells, Liu, Q., Bo. C., Wang, Q., Shi, X., Xiao, Z., Lin., J., and Fang, X. *, Nano Letters, 2009, 9: 1007-1010.
Study of inhibition effect of herceptin on interaction between heregulin and ErbB receptors HER3/HER2 by single-molecule force spectroscopy, Shi, X., Xu, L., Yu., J., and Fang, X. *, Exp. Cell. Res. 2009.
Molecular engineering of DNA: molecular beacons.K. Wang*, Z. Tang, C. Yang, Y. M. Kim, X. Fang, W. Li, Y. Wu, C. Medley, Z. Cao, J. Li, P. Colon, H. Lin, W. Tan*. Angew. Chem. Int. Ed., 2009, 48, 856-870.
Hydrodynamically Focused Stream as a Dynamic Template for Site-Specific Electrochemical Micropatterning of Conducting Polymers, Hou, S., Wang, S., Zeta, T., Yu, F., Nicole, Q., Zhu, M., Clifton, K,. Shen, F., Fang, X. *, Tseng, H.*, Angew. Chem. Int. Ed. 2008, 47,1072-1075
Single-Molecule Study of Lateral Mobility of Epidermal Growth Factor Receptor 2/HER2 on Activation，Z. Xiao, X. Ma, Y. Jiang, Z. Zhao, B. Lai, J. Liao, J. Yue and X. Fang*，J. Phy. Chem. B, 2008, 112: 4140-4145.
Detection of trace Hg2+ via induced circular dichroism of DNA wrapped around single-walled carbon nanotubes. X. Gao, G. Xing, Y. Yang, X. Shi, R. Liu, W. Chu, L. Jing, F. Zhao, C. Ye, H. Yuan, X. Fang, C. Wang, and Y. Zhao. J. Am. Chem. Soc., 2008, 130: 9190–9191.
TINY, a dehydration-responsive element(DRE)-binding protein-like transcription factor connecting the DRE-and ethylene-responsive element-mediated signaling patheways in Arabidopsis. S. Sun, J. Yu, F. Chen, T. Zhao, X. Fang, Y. Li, and S. Sui. J. Biol. Chem. 2008, 283: 6261-6271.
Single-Molecule Study of EGFR Mobility Implicates the its Association with Caveolae/Clathrin After Activation，Z. Xiao, W. Zhang, Y. Yang, L. Xu, X. Fang* Biochem Biophys Res Commun. 2008, 369: 730-734.
Conjugation of a Water-Soluble Gadolinium Endohedral Fulleride with an Antibody as a Magnetic Resonance Imaging Contrast Agent， Shu，C., Ma, X., Zhang, J., Corwin, F., Sim, J., Zhang, E., Dorn, H., Gibson, H., Fatouros, P., Wang, C.*, Fang, X. * Bioconjugate Chem., 2008, 19: 651-655.
Cell-specific Internalization study of an Aptamer From Whole Cell Selection, Xiao, Z., Shangguan, D., Cao, Z., Fang, X. and Tan, W. *, Chem. Eur. J., 2008, 14, 1679-1755.
Single Molecule Force Spectroscopy Study of Interaction between Transforming Growth Factor B and its Receptor in Living Cells，Yu., J., Wang Q., Shi X. , Ma, X., Yang H., Chen, Y., Fang, X*, J. Phy. Chem. B, 2007, 111(48):13619-13625
Lateral Diffusion of TGF-b Type Receptor Studied by Single Molecule Imaging, Ma, X., Wang,Q., Jiang, Y., Xiao, Z., Fang, X. *, Chen, Y*., Biochem Biophys Res Commun. 2007, 292, 31-40.
Interaction between Single Molecules of Mac-1 and ICAM-1 in Living Cells: An Atomic Force Microscopy Study, Yang, H., Yu, J. Fu, G., Shi, X., Xiao, L., Chen, Y., Fang, X*., Chen, H*., Exp. Cell. Res. 2007, 331, 3497-3504
Energy Landscape of Aptamer/Protein Complex Studied by Single Molecular Force Spectroscopy, Yu., J., Jiang, Y., Ma, X., Fang, X. * Chem. Asia. J., 2007, 2, 284-289.
Fluorescence study of DNA binding and bending by EcoRI DNA methyltransferase, Ma，B., Wang, J., Fang, X. *, J. Phy. Chem. B, 2006,110, 19647-19651.
Single Molecule Study of Binding Force Between Transcription Factor TINY and Its DNA Responsive Element, Yu, J., Sun, S., Jiang, Y., Ma, X., Chen, F., Zhang, G., Fang, X*., Polymer, 2006, 47, 2533-2538.
Detection of Oncoprotein Platelet-Derived Growth Factor Using Fluorescent Signaling Complex of Aptamer and TOTO，Zhou, C. Wang, J., Jiang, Y., Hou, S., Fang, X. *, Anal. Bioanal. Chem., 2006, 384, 1175-1180.
Aptamer Based ATP Assay Using a Luminescent Light Switching Complex, Wang, J., Jiang, Y., Zhou, C., Fang, X *. Anal. Chem., 2005, 77,3542-3546. (5.6)
Study of Fibrinogen Adsorption on Self-Assembled Monolayers on Au(111) by Atomic Force Microscopy，Lin ,Y., Wang, J., Wan L. , Fang X. *, Ultramicroscopy, 2005, 105, 129-136.
Study of the Single Molecular Interaction of the Transcription Factor ZmDREB1A with its DNA Responsive Element by Atomic Force Microscopy. Jiang, Y. X., Feng, Q., Fang, X*, Bai, C *. Nucl.Acid.Res. 2004, 32(12): e101.
Signaling Aptamer/Protein Binding by a Molecular Light-Switch Complex. Jiang, Y., Fang, X *, Bai, C *. Anal. Chem. 2004, 76, 5230-5235.
Delaying Photobleaching and Recovering Luminescence of a DNA Molecular Light Switch in DNA Analysis, Ling, L., Jiang, Y., Wang, C., Fang, X.*, Wan, L. He, Z., Bai, C.*, Chen.,D.*, Anal. Biochem. 2004, 329, 334-336.
Specific Aptamer - Protein Interaction Studied by Atomic Force Microscopy. Jiang, Y., Zhu, C. F., Ling, L., Wan, L., Fang, X *, Bai, C.*, Anal. Chem., 2003, 75(9): 2112-2116.
Study of Citrate Adsorbed on the Au(111) Surface by Scanning Probe Microscopy. Lin, Y., Pan, G.., Su, G. ., Fang, X.*, Wan, L.*., Bai, C.*. Langmuir 2003, 19, 10000-1003
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