中国科学院生物物理研究所考研导师卜鹏程介绍
作者：科大科院考研网 发表时间：2019-09-29 来源：研招办
中科院考研推荐链接：
卜鹏程 男 博导 中国科学院生物物理研究所
电子邮件： bupc@ibp.ac.cn
通信地址： 北京市朝阳区大屯路15号
邮政编码：
研究领域
非编码RNA，肿瘤代谢，肠道菌群
教育背景
2004-09--2007-07 中科院生物物理研究所 博士
2001-09--2004-07 大连理工大学 硕士
1997-09--2001-07 大连工业大学 学士
2001-09--2004-07 大连理工大学 硕士
1997-09--2001-07 大连工业大学 学士
工作经历
工作简历
2008-2010 美国加州大学伯克利分校， 博士后
2010-2015 美国康奈尔大学，研究助理
2015-2016 美国杜克大学，资深科学家
2016.09-至今 中科院生物物理研究所，研究员
指导学生
现指导学生
叶高琪 硕士研究生 071010-生物化学与分子生物学
张丽雯 硕士研究生 071010-生物化学与分子生物学
王智 硕士研究生 071009-细胞生物学
乔裕锋 硕士研究生 071009-细胞生物学
晁珊珊 博士研究生 071009-细胞生物学
专利与奖励
中组部“青年****”，国家级， 2017
中科院 率先行动“****” B类， 院级， 2016
北京市科学技术奖一等奖 (7/13)， 省级， 2014
中科院院长优秀奖，院级， 2007
中科院优秀毕业生，院级，2007
代表性论文
- Bu P#, Kaiyuan Chen,..., Shen X#. Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis. Cell Metabolism. 2018 27 (1-14). #, Corresponding author.
- Chen KY, Srinivasan T, Tung KL,…, Bu P#, Shen X#. A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal. Mol Syst Biol. 2017 13(4):927. #, Corresponding author.
- Bu P#, Wang L, Chen K-Y, …, Shen X#. miR-34a and Numb synergize for asymmetric cell fate determination to control stem cell proliferation. Cell Stem Cell. 2016 18(2):189-202. #, Corresponding author.
Highlighted in Cancer Discovery and AAAS
- Wang L*, Bu P*, Ai Y, et al. A large non-coding RNA regulates colon cancer stem cell asymmetric division. Elife. *, Co-first author. 2016; 10.7554/eLife.14620.
- Chen HJ,…,Bu P,…et al. A recellularized human colon model identifies cancer driver genes. Nat Biotechnol. 2016, doi: 10.1038/nbt.3586
- Srinivasan T, Walters J, Bu P,… et al. Notch signaling regulates asymmetric cell fate of fast- and slow-cycling colon cancer initiating cells. Cancer Res. 2016; DOI: 10.1158/0008-5472.CAN-15-3198.
- Srinivasan T, Than EB, Bu P et al. Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells. Sci Rep. 2016 16;6:26069. doi: 10.1038/srep26069
- Bu P#, Wang L, Chen K-Y, …, Shen X#. miR-1269 Promotes Metastasis through a Positive Feedback Loop with TGF-b. Nat commun. 2015 6:6879. #, Corresponding author.
- Sun S, …, Bu P…, et al. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol. 2015, 17(12):1546-55
- Li J, Ai Y, Wang L, Bu P,… et al. Targeted drug delivery to circulating tumor cells via platelet membrane-functionalized particles. Biomaterials. 2015 Oct 21;76:52-65
- Chen, H, …, Bu, P, …, et al. Chemokine-Targeted Mouse Models of Human Primary and Metastatic Colorectal Cancer. Nat Biotechnol. 2015, 33(6):656-60.
- Okada N, …, Bu P…, et al. A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression. Genes Dev. 2014 28: 438-450
- Bu P, Chen K-Y, Chen JH et al. A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells. Cell Stem Cell. 2013, 12(5):602-625.
Highlighted in Cell Stem Cell and Biotechniques.
- Bu P, Chen K-Y, Lipkin SM, Shen X. Asymmetric division: a marker for cancer stem cells in early stage tumors? Oncotarget. 2013, 4(7):950-951.
- Chen JH Edwards R, Tucci S, Bu P, et al. The chemokine 25 and chemokine receptor 9 axis suppresses colon cancer invasion and metastasis. J Clin Invest. 2012, 122(9):3184-96
- 15. Choi YJ, …, Bu P, …, et al. miR-34a miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol. 2011, 13(11):1353-60.
- Bu P, Zhuang J, Feng J, et al. Visualization of CD146 dimerization and its regulation in living cells. BBA-Mol Cell Res. 2007, 1773(4):513-20.1.
- Bu P, Gao L, Zhuang J, et al. Anti-CD146 monoclonal antibody, AA98, inhibits angiogenesis via suppression of NF-kB activation. Mol Caner Ther. 2006, 5(11): 2872-2878
