(1) Thousand Talent Plan by Zhejiang Province, HKU-ZIRI, 一等奖, 省级, 2017
(2) Global Talent Scheme “521” Plan by Hangzhou City, HKU-ZIRI, 一等奖, 市地级, 2017
(3) Outstanding Researcher Award 2014-2015, the University of Hong Kong, 特等奖, 研究所(学校), 2016
(4) SRT D & R Best Research Output Prize - 1st Prize, the University of Hong Kong, 一等奖, 研究所(学校), 2014
(5) 香港大学杰出青年学者奖, 一等奖, 研究所(学校), 2006
(6) 美国国家健康研究院(NIH)杰出成就奖, 一等奖, 国家级, 1999
专利成果
( 1 ) HOST CELLS DEFICIENT FOR MISMATCH REPAIR AND THEIR USE IN METHODS FOR INDUCING HOMOLOGOUS RECOMBINATION USING SINGLE-STRANDED NUCLEIC ACIDS., 2004, 第 1 作者, 专利号: PCT/US03/14657
( 2 ) TWO-WAY, PORTABLE RIBOSWITCH MEDIATED GENE EXPRESSION CONTROL DEVICE, 2017, 第 1 作者, 专利号: ZL201280032539.4
( 3 ) Modified Bacteria and their Uses thereof for the Treatment of Cancer, 2015, 第 1 作者, 专利号: US 9,127,284 B2
( 4 ) Two-way,portable riboswitch mediated gene expression control device, 2015, 第 1 作者, 专利号: US9222093B2
出版信息
发表论文
(1) Synthetic circuits that process multiple light and chemical signal inputs, BMC Systems Biology, 2017, 第 11 作者
(2) Multimodal Nonlinear Optical Microscopy Reveals Critical Role of Kinesin-1 in Cartilage Development, Biomedical Optics Express, 2017, 第 11 作者
(3) Blocking the Recruitment of Naïve CD4+ T Cells Reverses Immunosuppression in Breast Cancer, Cell Research, 2017, 第 11 作者
(4) Angiogenic inhibitors delivered by the type III secretion system of tumor-targeting Salmonella typhimurium safely shrink tumors in mice, AMB Express, 2016, 第 11 作者
(5) Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex, The Journal of Cell Biology, 2016, 第 11 作者
(6) A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile, BMC Infectious Diseases, 2016, 第 11 作者
(7) An “obligate” anaerobic Salmonella strain YB1 suppresses liver tumor growth and metastasis in nude mice, Oncology Letters, 2016, 第 11 作者
(8) Adipose-specific Deletion of Kif5b Exacerbates Obesity and Insulin Resistance in a Mouse Model of Diet-induced Obesity, FASEB Journal, 2016, 第 11 作者
(9) Modification of the RpoS network with an artificial small RNA, Nucleic Acids Research, 2013, 第 11 作者
(10) Comparative immunological evaluation of recombinant Salmonella Typhimurium strains expressing model antigens as live oral vaccines, BMC Immunology, 2012, 第 11 作者
(11) Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in, Neurobiology of Aging, 2012, 第 11 作者
(12) Sequential establishment of stripe patterns in an expanding cell population, Science, 2011, 第 11 作者
(13) Engineering a portable riboswitch-LacP hybrid device for two-way gene regulation, Nucleic Acids Research, 2011, 第 11 作者
(14) Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells, Molecular Cancer, 2011, 第 11 作者
(15) Use of a riboswitch-controlled conditional hypomorphic mutation to uncover a role for the essential CsrA gene in bacterial autoaggregation, Journal of Biological Chemistry, 2009, 第 11 作者
(16) Direct interaction of microtubule- and actin-based transport motors, Nature, 1998, 第 11 作者
发表著作
Combined prokaryotic-eukaryotic delivery and expression of therapeutic factors through a primed autocatalytic positive-feedback loop, Journal of Controlled Release, 2016-07, 第 5 作者
Synthetic circuits that process multiple light and chemical signal inputs, BMC Systems Biology, 2017-01, 第 3 作者
Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model, Journal of Infectious Diseases, 2017-06, 第 1 作者
科研活动
科研项目
( 1 ) 合成生物器件干预膀胱癌的基础研究, 主持, 国家级, 2014-01--2018-08
( 2 ) Pattern formation by bacteria : form theoretical physics to synthetic biology, 主持, 研究所(学校), 2015-06--2018-05
( 3 ) A feasibility study on the inhibition of Staphylococcus aureus infection using AdsA specific antibodies., 主持, 研究所(学校), 2015-06--2017-05
( 4 ) Characterization of the interaction between Kif5b and NMDAR in ischemic provoked neurodegeneration., 主持, 省级, 2016-09--2018-08
( 5 ) 人工改造细菌治疗癌症新技术的研发, 主持, 省级, 2015-11--2020-11
( 6 ) 合成生物学手段改造微生物抑制癌症转移的研究., 主持, 省级, 2017-06--2020-06
参与会议
(1)Sequential Establishment of Stripe Patterns in an Expanding Cell Population 2014-06-12
(2)合成生物学方法编码细胞的时空分布 2011年中山大学孙逸仙纪念医院乳腺肿瘤医学部年终会议 2011-12-30